Construction and Evaluation of Paclitaxel Mn-Doped Dendritic Mesoporous Silica Coated with N-Succinyl Chitosan

Abstract

Mesoporous silica, as a drug carrier, has become the new research focus in the field of nanodrug delivery system in recent years. In this study, Mn-doped mesoporous silicas are synthesized by template and in-situ doping method and physically characterized. The drug-loading performance of silica and its impact on drug release are studied. The Mn-doped mesoporous silicas show dendritic morphology (MDMS) with a loose wrinkle structure on the surface and a large number of pores. MDMS is used as a carrier to solve the problem of low water solubility of paclitaxel. In order to avoid leakage during drug transportation, the surface of Mn-doped mesoporous silica loaded with paclitaxel is coated with N-succinyl chitosan to construct a new type of nanodrug delivery system (MDMS-PTX-NSC). Compared to MDMS, MDMS-PTX-NSC shows an increase in particle size and smooth surface. The dissolution characteristics of manganese ions and swelling behavior of N-succinyl chitosan make MDMS-PTX-NSC delivery system exhibit a good pH-responsive release. And MDMS-PTX-NSC release curve can be well fitted by Ritger-Peppas equation. The cytotoxicity test shows that the MDMS-PTX-NSC has significant biocompatibility and enhanced cytotoxicity, which reveals that the MDMS-PTX-NSC is a promising nanodrug delivery system.