CLAY NANOTUBES FOR ENCAPSULATION AND SUSTAINED RELEASE OF DRUGS-Reference-Cited by-同舟云学术

CLAY NANOTUBES FOR ENCAPSULATION AND SUSTAINED RELEASE OF DRUGS

Published:2007-04 Issue:02 Volume:02 Page:115-120
ISSN:1793-2920
Container-title:Nano
language:en
Short-container-title:NANO

Author:

VEERABADRAN NALINKANTH G.¹,PRICE RONALD R.²,LVOV YURI M.¹

Affiliation:

1. Institute for Micromanufacturing, Louisiana Tech University, Ruston, Louisiana-71272, USA

2. Nanoclay and Technology Division, Atlas Mining Corporation, Eureka, Utah-84628, USA

Abstract

50-nm diameter halloysite clay nanotubules with 15 nm lumen were used for loading poorly soluble drugs and sustaining their release. Loading was optimized by varying pH and alcohol/water ratio in the solvent with a maximum drug loading of 12 volume%. Near linear release of Dexamethasone, Furosemide, and Nifedipine was demonstrated for 5–10 hours. Its capacity for the time release of drugs, along with its simple loading procedure and the biocompatibility of halloysite nanotubules makes this method a prospective drug delivery system.

Publisher

World Scientific Pub Co Pte Lt

Subject

Condensed Matter Physics,General Materials Science

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1793292007000441

Reference13 articles.

1. In-vitro release characteristics of tetracycline HCl, khellin and nicotinamide adenine dineculeotide from halloysite; a cylindrical mineral

2. Halloysite clay minerals — a review

3. Characterisation of halloysite for use as a microtubular drug delivery system

4. Use of coated microtubular halloysite for the sustained release of diltiazem hydrochloride and propranolol hydrochloride

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