Biomedical applications of Jones-matrix tomography to polycrystalline films of biological fluids

Author:

Ushenko V. A.1,Sdobnov A. Yu.2ORCID,Mishalov W. D.3,Dubolazov A. V.14,Olar O. V.1,Bachinskyi V. T.5,Ushenko A. G.1,Ushenko Yu. A.1,Wanchuliak O. Ya.5,Meglinski I.26748

Affiliation:

1. Chernivtsi National University, 2 Kotsiubynskyi St., Chernivtsi, 58012 Ukraine

2. Faculty of Information Technology and Electrical Engineering, University of Oulu, Oulu 90570, Finland

3. Shupyk National Medical Academy of Postgraduate Education, 9, Dorogozhytska St., Kyiv, 04112 Ukraine

4. Aston Institute of Materials Research, School of Engineering and Applied Science, Aston University, Birmingham, B4 7ET, UK

5. Bukovinian State Medical University, 3 Theatral Sq., Chernivtsi, 58000 Ukraine

6. Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Tomsk, 634050 Russia

7. Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University “MEPhI”, Moscow, 15409 Russia

8. School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK

Abstract

Algorithms for reconstruction of linear and circular birefringence-dichroism of optically thin anisotropic biological layers are presented. The technique of Jones-matrix tomography of polycrystalline films of biological fluids of various human organs has been developed and experimentally tested. The coordinate distributions of phase and amplitude anisotropy of bile films and synovial fluid taken from the knee joint are determined and statistically analyzed. Criteria (statistical moments of 3rd and 4th orders) of differential diagnostics of early stages of cholelithiasis and septic arthritis of the knee joint with excellent balanced accuracy were determined. Data on the diagnostic efficiency of the Jones-matrix tomography method for polycrystalline plasma (liver disease), urine (albuminuria) and cytological smears (cervical cancer) are presented.

Funder

Academy of Finland

the MEPhI Academic Excellence Project

Publisher

World Scientific Pub Co Pte Lt

Subject

Biomedical Engineering,Atomic and Molecular Physics, and Optics,Medicine (miscellaneous),Electronic, Optical and Magnetic Materials

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