THE EXPERIMENTAL STUDY OF STRESS-RELATED PATHOLOGICAL CHANGES IN CEREBRAL VENOUS BLOOD FLOW IN NEWBORN RATS ASSESSED BY DOCT-Reference-Cited by-同舟云学术

THE EXPERIMENTAL STUDY OF STRESS-RELATED PATHOLOGICAL CHANGES IN CEREBRAL VENOUS BLOOD FLOW IN NEWBORN RATS ASSESSED BY DOCT

Published:2013-07 Issue:03 Volume:06 Page:1350023
ISSN:1793-5458
Container-title:Journal of Innovative Optical Health Sciences
language:en
Short-container-title:J. Innov. Opt. Health Sci.

Author:

SEMYACHKINA-GLUSHKOVSKAYA OXANA V.¹,LYCHAGOV VLADISLAV V.¹,BIBIKOVA OLGA A.¹,SEMYACHKIN-GLUSHKOVSKIY IGOR A.¹,SINDEEV SERGEY S.¹,ZINCHENKO EKATERINA M.¹,KASSIM MOHHANAD M.¹²,ALI AL-FATLE FATEMA¹²,LEITH AL HASSANI¹²,ULANOVA MARIA V.¹,TUCHIN VALERY V.¹³⁴

Affiliation:

1. Department of Biology, Saratov State University, Astrachanskaya Str. 83, 410012 Saratov, Russian Federation

2. Department of Biology, Al-Mustansiriya University, Baghdad, Iraq

3. Institute of Precise Mechanics and Control of Russia Academy of Science, Rabochaya 28, 410028 Saratov, Russian Federation

4. Optoelectronics and Measurement Techniques Laboratory, University of Oulu, P.O. BOX 4500 90014, University of Oulu, Finland

Abstract

In experiments on newborn rats with stress-related intracranial hemorrhage (ICH) using Doppler optical coherence tomography (DOCT) we have shown that latent stage of ICH (4 h after stress) is characterized by decrease of venous blood outflow and the loss of sensitivity of sagittal vein to vasoconstrictor effect of adrenaline. The incidence of ICH (24 h after stress) was accompanied by progression of early pathological changes in cerebral venous blood flow (CVBF) and development of venous insufficiency. Taking into consideration of this fact, we suggest that the suppression of CVBF related to the severity to the deleterious effect of stress on the brain hemodynamics in newborn rats. These facts allow us to conclude that the venous insufficiency with the loss of vasoconstrictor response to adrenaline is an informative and sensitive component of pattern of CVBF that can be important diagnostic criteria of risk of ICH development in newborns.

Publisher

World Scientific Pub Co Pte Lt

Subject

Biomedical Engineering,Atomic and Molecular Physics, and Optics,Medicine (miscellaneous),Electronic, Optical and Magnetic Materials

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1793545813500235

Reference66 articles.

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