Three-dimensional imaging of spatio-temporal dynamics of small blood capillary network in the cortex based on optical coherence tomography: A review

Author:

Xing Fangjian12ORCID,Lee Jang-Hoon2,Polucha Collin2,Lee Jonghwan23

Affiliation:

1. Jiangsu Key Laboratory for Opto-Electronic Technology, School of Physics and Technology, Nanjing Normal University, Nanjing 210023, P. R. China

2. Center for Biomedical Engineering, School of Engineering, Brown University, Providence, Rhode Island, USA

3. Carney Institute for Brain Science, Brown University, Providence, RI 02906, USA

Abstract

Optical coherence tomography angiography (OCTA) has emerged as an advanced in vivo imaging modality, which is widely used for the clinic ophthalmology and neuroscience research in the rodent brain cortex among others. Based on the high numerical aperture (NA) probing lens and the motion-corrected algorithms, a high-resolution imaging technique called OCT micro-angiography is applied to resolve the small blood capillary vessels ranging from 5[Formula: see text][Formula: see text]m to 10[Formula: see text][Formula: see text]m in diameter. As OCT-based techniques are recently evolving further from the structural imaging of capillaries toward spatio-temporal dynamic imaging of blood flow in capillaries, here we present a review on the latest techniques for the dynamic flow imaging. Studies on capillary blood flow using these techniques will help us better understand the roles of capillary blood flow for normal functioning of the brain as well as how it malfunctions in diseases.

Funder

NIH/NIBIB

Brown University

Basic Research Program of Jiangsu Province

Publisher

World Scientific Pub Co Pte Lt

Subject

Biomedical Engineering,Atomic and Molecular Physics, and Optics,Medicine (miscellaneous),Electronic, Optical and Magnetic Materials

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