Three-dimensional quantification of protoporphyrin IX in photodynamic therapy using SFDI/DFT: A pilot experimental validation

Author:

Dan Mai1ORCID,Song Weijie2,Liu Meihui1ORCID,Zhang Yaru1,Gao Feng13

Affiliation:

1. College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, P. R. China

2. Tianjin Medical University, Cancer Institute and Hospital, Tianjin 300000, P. R. China

3. Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, P. R. China

Abstract

Photodynamic therapy (PDT) dosimetry, including light dose, photosensitizer dose and tissue oxygen, has been a research focus in PDT. In this work, we present a three-dimensional (3D) quantification of protoporphyrin IX (PpIX) using combined spatial frequency domain imaging (SFDI) and diffuse fluorescence tomography (DFT). The SFDI maps both the distributions of tissue absorption and scattering properties at three wavelengths and accordingly provides the optical background for DFT and extracts the tissue oxygenation for assessing the therapeutic outcomes, while DFT dynamically monitors the 3D distribution of PpIX dose from measured fluorescence signals for the procedure optimization. A pilot in vivo application in tumor nude models showed that the proposed SFDI/DFT is able to dynamically trace changes in the PpIX concentration and tissue oxygen during the treatment, rendering it a potentially powerful tool for PDT to improve clinical efficacy.

Funder

National Natural Science Foundation of China

Publisher

World Scientific Pub Co Pte Ltd

Subject

Biomedical Engineering,Atomic and Molecular Physics, and Optics,Medicine (miscellaneous),Electronic, Optical and Magnetic Materials

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Special issue on enhanced photodynamic therapy: Part II;Journal of Innovative Optical Health Sciences;2022-11

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