Construction of Au@Metal-organic framework for sensitive determination of creatinine in urine

Author:

Jiang Yuning1,Cai Yanzheng1,Hu Sen1,Guo Xiaoyu1,Ying Ye1,Wen Ying1,Wu Yiping1,Yang Haifeng1ORCID

Affiliation:

1. College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, P. R. China

Abstract

Creatinine level in urine is an important biomarker for renal function diseases, such as renal failure, glomerulonephritis, and chronic nephritis. The Au@MIL-101(Fe) was prepared by in situ growth of Au nanoparticles in MIL-101(Fe) as a selective SERS substrate. The Au@MIL-101(Fe) offers the great local surface plasmon resonance (SPR) effect due to gold nanoparticles aggregation inside metal-organic frameworks. The framework structure could enrich trace target samples and drag them into SPR hot spots. The optimal Au@MIL-101(Fe) composite substrate is used for analyzing creatinine in urine and the limit of detection is down to 0.1[Formula: see text][Formula: see text]mol/L and a linear relationship is ranging from 1[Formula: see text][Formula: see text]mol/L to 100[Formula: see text][Formula: see text]mol/L.

Funder

National Natural Science Foundation of China

Publisher

World Scientific Pub Co Pte Lt

Subject

Biomedical Engineering,Atomic and Molecular Physics, and Optics,Medicine (miscellaneous),Electronic, Optical and Magnetic Materials

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