Laser speckle contrast imaging for monitoring of acute pancreatitis at ischemia–reperfusion injury of the pancreas in rats-Reference-Cited by-同舟云学术

Laser speckle contrast imaging for monitoring of acute pancreatitis at ischemia–reperfusion injury of the pancreas in rats

Published:2021-11-19 Issue:01 Volume:15 Page:
ISSN:1793-5458
Container-title:Journal of Innovative Optical Health Sciences
language:en
Short-container-title:J. Innov. Opt. Health Sci.

Author:

Timoshina P. A. Dyachenko¹²^ORCID,Bashkatov A. N.¹²,Alexandrov D. A.³,Kochubey V. I.¹,Tuchin V. V.²⁴⁵^ORCID

Affiliation:

1. Saratov State University, Saratov, Russia

2. Laboratories of Biophotonics and Laser Molecular, Imaging and Machine Learning, National Research Tomsk State University, Tomsk, Russia

3. Saratov State Medical University, Saratov, Russia

4. Institute of Precision Mechanics and Control, Russian Academy of Sciences, Russia

5. A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia

Abstract

The influence of ischemia–reperfusion (I/R) action on pancreatic blood flow (PBF) and the development of acute pancreatitis (AP) in laboratory rats is evaluated in vivo by using the laser speckle contrast imaging (LSCI). Additionally, the optical properties in norm and under condition of AP in rats were assessed using a modified integrating sphere spectrometer and inverse Monte Carlo (IMC) software. The results of the experimental study of microcirculation of the pancreas in 82 rats in the ischemic model are presented. The data obtained confirm the fact that local ischemia and changes in the blood flow velocity of the main vessels cause and provoke acute pancreatitis.

Funder

grant RF

Publisher

World Scientific Pub Co Pte Ltd

Subject

Biomedical Engineering,Atomic and Molecular Physics, and Optics,Medicine (miscellaneous),Electronic, Optical and Magnetic Materials

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1793545822420020

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