A High-Performance Fast Capacitance Compensation Method

Abstract

In the widely used single-molecule Deoxyribonucleic Acid (DNA) sequencing and patch-clamp technique, the fast capacitance (C-Fast) noise in application circuit affects the accuracy of the system measurement. In this paper, a high-performance C-Fast compensation method based on compensation circuit and fuzzy adaptive algorithm is proposed. The model of C-Fast noise is analyzed and a C-Fast compensation circuit is designed, whose parameters can be automatically calculated and adjusted by fuzzy adaptive algorithm. The method is validated through simulations and experiments on the test setup. The results indicate that the proposed method can effectively eliminate the C-Fast noise and improve the measurement accuracy.