INJECTABLE OXYGEN DELIVERY BASED ON PROTEIN-SHELLED MICROBUBBLES

Author:

SWANSON EDWARD J.1,BORDEN MARK A.2

Affiliation:

1. Chemical Engineering, Columbia University, 500 West 120th Street, New York, NY 10027, USA

2. Mechanical Engineering, University of Colorado, 1111 Engineering Drive, Boulder, CO 80309, USA

Abstract

Injectable oxygen delivery is an emerging technology that presents an opportunity for improved patient care in a number of medical disciplines. Here, we report on the fabrication and characterization of novel protein-encapsulated oxygen microbubbles (OMBs) designed for intravenous injection. The nanothick albumin encapsulation provided OMBs small enough for transcapillary passage: 99% of the microbubbles were less than 3-μm diameter and less than 1% of the oxygen was encapsulated in microbubbles greater than 8-μm diameter. The protein OMBs were remarkably stable, losing less than 40% of the encapsulated gas over 12 days. Upon injection into an oxygen-depleted saline solution, the protein OMBs rapidly equilibrated by releasing their oxygen core. These results indicate that protein microbubbles may serve as a suitable platform for direct injection of bioactive and therapeutic gases.

Publisher

World Scientific Pub Co Pte Lt

Subject

General Medicine

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