Design and Gene Delivery Application of Polymeric Materials in Cancer Immunotherapy

Abstract

Immunotherapy has offered an alternative therapy method for cancer patients with metastatic tumors or who are not suitable for surgical resection. Different from traditional surgery, radiotherapy and chemotherapy, immunotherapy mainly restores the activity of the body’s own immune cells silenced in the tumor microenvironment to achieve anticancer therapy. Gene therapy which corrects abnormal expression of immune cells in tumor microenvironment by delivering exogenous genes to specific immune cells, is the most widely studied immunotherapy. Although most available gene delivery vectors are still viral vectors, the further application of viral vectors is still limited by the immunogenicity and mutagenesis. Based on this, cationic polymeric gene vectors with high flexibility, high feasibility, low cost and high safety have been widely used in gene delivery. The structural variability of polymers allows specific chemical modifications to be incorporated into polymer scaffolds to improve their physicochemical properties for more stable loading of genes or more targeted delivery to specific cells. In this review, we have summarized the structural characteristics and application potential in cancer immunotherapy of these polymeric gene vectors based on poly(L-lysine), poly(lactic-co-glycolic acid), polyethyleneimine, poly(amidoamine) and hydrogel system.