Single-Walled Carbon Nanotube-Based Biosensors for Detection of Bronchial Inflammation

Abstract

Inflammation is a protective mechanism against invading pathogens and tissue damage. However, the inflammatory process is implicated in a wide range of diseases affecting all organs and body systems. Nitric oxide — a multifunctional signaling molecule that plays a critical role in systemic blood pressure homeostasis, prevention of platelet aggregation, antimicrobial resistance, immunoregulation, tumor suppression and as a neurotransmitter — is used as a surrogate marker for inflammation. However, the most commonly used Griess assay is an indirect and expensive method for the determination of nitric oxide concentration. Hence, single-walled carbon nanotube-based biosensors have been explored as real-time, sensitive, selective and safe methods to determine nitric oxide released during the inflammatory process. In this review, we explore current developments in single-walled carbon nanotube-based biosensors for the detection of nitric oxide in exhaled breath as a direct and noninvasive test for detection of bronchial inflammation.