Affiliation:
1. Department of Biotechnology and Life Sciences, Sharda University, Plot No. 32-34, Knowledge Park III, Greater Noida, Uttar Pradesh 201310, India
2. Life Sciences, Wollo University, Dessie, South Wollo 1145, Ethiopia
Abstract
Silver nanoparticles (AgNPs) have attracted a great deal of attention in the recent years. It is mostly due to their availability, chemical stability, catalytic activity, conductivity, biocompatibility and anticancer activity. There are three major approaches for AgNPs synthesis; i.e., chemical, physical, and biological methods. Today, many chemical and physical methods have become less popular due to usage of hazardous chemicals or their high costs, respectively. The green method has introduced an appropriate substitute synthesis strategy for the conventional physical and chemical approaches. The utilization of the plant extracts as reducing, stabilizing and coating agent of AgNPs is an interesting eco-friendly approach leading to high efficiency. The anticancer synergistic effects among the AgNPs and phytochemicals will enhance their therapeutic potentials. Surprisingly, although many studies have demonstrated the significant enhancement in cytotoxic activities of plant-mediated AgNPs toward cancerous cells, these nanoparticles (NPs) have been found nontoxic to normal human cells in their therapeutic concentrations. This paper provides a specific insight into the mechanism of plant-mediated AgNPs synthesis, their anticancer and cytotoxic activities in vitro cancer cells, in vivo model animals and clinical trials.
Publisher
World Scientific Pub Co Pte Lt
Subject
Electrical and Electronic Engineering,Computer Science Applications,Condensed Matter Physics,General Materials Science,Bioengineering,Biotechnology
Reference105 articles.
1. Use of Nanotechnology to Develop Multi-Drug Inhibitors for Cancer Therapy
2. R. B. S. M. N. Mydin, W. N. Rahman, R. M. Lazim, A. Mohd Gazzali, N. H. M. Azlan and S. Moshawih, in Nanotechnology: Applications in Energy, Drug and Food, Shafiquzzaman Siddiquee, Gan Jet Hong Melvin and Md Mizanur Rahman, (eds.), Vol. 1 (Springer International Publishing, Cham, 2019), p. 187.
3. Biosynthesized Silver Nanoparticle (AgNP) From Pandanus odorifer Leaf Extract Exhibits Anti-metastasis and Anti-biofilm Potentials
4. Effects of green-synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors in vivo
5. In vitro evaluation of antioxidant and anticancer potential of Morinda pubescens synthesized silver nanoparticles
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