Magnetoresistive Biosensors for Direct Detection of Magnetic Nanoparticle Conjugated Biomarkers on a Chip-Reference-Cited by-同舟云学术

Magnetoresistive Biosensors for Direct Detection of Magnetic Nanoparticle Conjugated Biomarkers on a Chip

Published:2019-06 Issue:02 Volume:09 Page:1940002
ISSN:2010-3247
Container-title:SPIN
language:en
Short-container-title:SPIN

Author:

Huang H. T.¹²,Garu P.¹,Li C. H.¹²,Chang W. C.³,Chen B. W.¹,Sung S. Y.⁴,Lee C. M.⁵,Chen J. Y.⁶,Hsieh T. F.⁷,Sheu W. J.²,Ouyang H.⁸,Wang W. C.¹²,Chang C. R.⁹,Wang C. L.¹⁰,Hsu M. S.¹⁰,Wei Z. H.¹²

Affiliation:

1. Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu, Taiwan

2. Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan

3. Department of Neurosurgery, Show Chwan Memorial Hospital, Changhua, Taiwan

4. Program for Translational Medicine College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

5. Graduate School of Materials Science, National Yunlin University of Science and Technology, Douliou, Taiwan

6. Research Center for Sustainable Energy and Nanotechnology, National Chung Hsing University, Taichung, Taiwan

7. Department of Urology, Buddhist Tzu Chi General Hospital, Taichung, Taiwan

8. Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu, Taiwan

9. Department of Physics, National Taiwan University, Taipei, Taiwan

10. Department of Obstetrics and Gynecology, Ching-Kuo Campus of Min-Sheng Hospital, Taoyuan, Taiwan

Abstract

In this review, we introduce various magnetic biosensors that have been developed. We first explain the advantages of magnetic biosensing and their general operating principles as well as the biolabeling technique for magnetic nanoparticles. Next, we focus on magnetoresistive biosensing technologies because magnetoresistive biosensors will be an essential development direction due to the demand for miniaturization and portable lab-on-a-chip devices. The magnetoresistive effects employed in biosensing include anisotropic magnetoresistance, giant magnetoresistance and tunneling magnetoresistance. In addition to magnetoresistive sensors, the advantages and disadvantages of some nonmagnetoresistive magnetic biosensors are discussed and compared. Finally, we introduce research on integrating magnetic biosensors into the microfluidic laboratory-on-a-chip systems and comment on future development trends.

Funder

Ministry of Science and Technology, Taiwan

Publisher

World Scientific Pub Co Pte Lt

Subject

Electrical and Electronic Engineering,Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials

Link

https://www.worldscientific.com/doi/pdf/10.1142/S2010324719400022

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