Interaction of Methylene Blue with Synthetic Polynucleotide Poly(dA)-Poly(dT)-Reference-Cited by-同舟云学术

Interaction of Methylene Blue with Synthetic Polynucleotide Poly(dA)-Poly(dT)

Published:2018-03 Issue:01 Volume:13 Page:29-36
ISSN:1793-0480
Container-title:Biophysical Reviews and Letters
language:en
Short-container-title:Biophys. Rev. Lett.

Author:

Parsadanyan Marine A.¹,Antonyan Ara P.¹,Vardevanyan Poghos O.¹,Sngryan Hakob E.²

Affiliation:

1. Department of Biophysics, Faculty of Biology, Yerevan State University, A. Manoogian 1, Yerevan 0025, Armenia

2. Chair of Medical Physics, Yerevan State Medical University, Koryun 2, Yerevan 0025, Armenia

Abstract

The interaction of methylene blue (MB) with poly(dA)-poly(dT) has been studied. It was revealed that MB binds to this polynucleotide by strong and weak modes. It was shown that the strong binding mode of MB is realized by semi-intercalation. Apart from the strong mode, this ligand binds to AT-sequences by weak electrostatic modes as well. Values of the binding constant [Formula: see text] and number of base pairs [Formula: see text] per binding site of MB for the mentioned modes were determined. It was shown that at the interaction with AT sequences MB does not behave itself as a groove binding compound.

Publisher

World Scientific Pub Co Pte Lt

Subject

Molecular Biology,Structural Biology,Biophysics

Link

https://www.worldscientific.com/doi/pdf/10.1142/S1793048018500030

Reference25 articles.

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2. Spectroscopic, calorimetric, cyclic voltammetric and molecular modeling studies of new methylene blue-polyadenylic acid interaction and comparison to thionine and toluidine blue O: Understanding self-structure formation by planar dyes

3. Study on the interaction of glycyrrhizin and glycyrrhetinic acid with RNA

4. The Melanoma‐Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion

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