CANCER — PATHOLOGICAL BREAKDOWN OF COHERENT ENERGY STATES

Author:

POKORNÝ JIŘÍ1,POKORNÝ JAN2,KOBILKOVÁ JITKA3,JANDOVÁ ANNA4,VRBA JAN5,VRBA JAN6

Affiliation:

1. Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, Prague 8–Kobylisy, 182 51, Czech Republic

2. Institute of Physics, Academy of Sciences of the Czech Republic, Na Slovance 2, Prague 8, 182 21, Czech Republic

3. 1st Faculty of Medicine, Department of Obstetrics and Gynaecology, Charles University, Apolinářská 18, Prague 2, 128 00, Czech Republic

4. Tyršova 415, Šestajovice, 250 92, Czech Republic

5. Faculty of Electrical Engineering, Czech Technical University in Prague, Technická 2, Prague 6, 166 27, Czech Republic

6. Faculty of Biomedical Engineering, Czech Technical University in Kladno, Sitná Square 3105, Kladno, 272 01, Czech Republic

Abstract

The fundamental property of biological systems is a coherent state far from thermodynamic equilibrium excited and sustained by energy supply. Mitochondria in eukaryotic cells produce energy and form conditions for excitation of oscillations in microtubules. Microtubule polar oscillations generate a coherent state far from thermodynamic equilibrium which makes possible cooperation of cells in the tissue. Mitochondrial dysfunction (the Warburg effect) in cancer development breaks down energy of the coherent state far from thermodynamic equilibrium and excludes the afflicted cell from the ordered multicellular tissue system. Cancer lowering of energy and coherence of the state far from thermodynamic equilibrium is the biggest difference from the healthy cells. Cancer treatment should target mitochondrial dysfunction to restore the coherent state far from thermodynamic equilibrium, apoptotic pathway, and subordination of the cell in the tissue. A vast variety of genetic changes and other disturbances in different cancers can result in several triggers of mitochondrial dysfunction. In cancers with the Warburg effect, mitochondrial dysfunction can be treated by inhibition of four isoforms of pyruvate dehydrogenase kinases. Treatment of the reverse Warburg effect cancers would be more complicated. Disturbances of cellular electromagnetic activity by conducting and asbestos fibers present a special problem of treatment.

Publisher

World Scientific Pub Co Pte Lt

Subject

Molecular Biology,Structural Biology,Biophysics

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Electromagnetic communication between cells through tunneling nanotubes;International Journal of Microwave and Wireless Technologies;2020-05-13

2. Moving the systemic evolutionary approach to cancer forward: Therapeutic implications;Medical Hypotheses;2018-12

3. Warburg effect—damping of electromagnetic oscillations;Electromagnetic Biology and Medicine;2017-06-02

4. Energy parasites trigger oncogene mutation;International Journal of Radiation Biology;2016-09-07

5. Mitochondrial Dysfunction and Disturbed Coherence: Gate to Cancer;Pharmaceuticals;2015-09-30

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