Ethyl Acetate Extract of the Stem Bark of Cudrania Tricuspidata Induces Apoptosis in Human Leukemia HL-60 Cells-Reference-Cited by-同舟云学术

Ethyl Acetate Extract of the Stem Bark of Cudrania Tricuspidata Induces Apoptosis in Human Leukemia HL-60 Cells

Published:2001-01 Issue:02 Volume:29 Page:313-320
ISSN:0192-415X
Container-title:The American Journal of Chinese Medicine
language:en
Short-container-title:Am. J. Chin. Med.

Author:

Seo Won-Gil¹²,Pae Hyun-Ock¹²,Oh Gi-Su²,Chai Kyu-Yun²,Yun Young-Gab³,Chung Hun-Taeg¹²,Jang Kyu Kwan⁴,Kwon Tae-Oh²⁵

Affiliation:

1. Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Chonbuk 570-749, South Korea

2. Medicinal Resources Research Center of Wonkwang University, Wonkwang University, Iksan, Chonbuk 570-749, South Korea

3. Department of Prescription, School of Oriental Medicine, Iksan, Chonbuk 570-749, South Korea

4. Botanical Garden, Wonkwang University, Iksan, Chonbuk 570-749, South Korea

5. College of Life Science and Natural Resources, Iksan, Chonbuk 570-749, South Korea

Abstract

Apoptosis is now widely accepted as playing a role in tumorigenesis. An effective compound which can kill tumors via apoptonic pathway appears to be a relevant strategy to suppress various human tumors. The ethyl acetate extract from the stem bark of Cudrania tricupidata (EACT) showed dose- and time-dependent cytotoxic effects on human leukemia HL-60 cells. DNA fragmentation and morphological changes, accompanied by condensed and fragmented nuclei, were observed in the cells cultured for 6 hr with EACT. These results suggest that the cytotoxicity of the crude extract from Cudrania tricuspidata against HL-60 cells is due to apoptosis.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0192415X01000332

Reference16 articles.

1. Clofilium, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3

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