Actinidia rubricaulisAttenuates Hepatic Fibrosis Induced by Carbon Tetrachloride in Rats-Reference-Cited by-同舟云学术

Actinidia rubricaulisAttenuates Hepatic Fibrosis Induced by Carbon Tetrachloride in Rats

Published:2007-01 Issue:01 Volume:35 Page:81-88
ISSN:0192-415X
Container-title:The American Journal of Chinese Medicine
language:en
Short-container-title:Am. J. Chin. Med.

Author:

Liao Jung-Chun¹²,Lin Kun-Hung¹,Cheng Hao-Yuan¹,Wu Jin-Bin³,Hsieh Ming-Tsuen¹,Peng Wen-Huang¹

Affiliation:

1. Graduated Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan, ROC

2. Center of General Education, China Medical University, Taichung, Taiwan, ROC

3. Graduated Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan, ROC

Abstract

The purpose of this study was to evaluate the antioxidant activity and hepatoprotective effect of ethanol extracts of Actinidia rubricaulis (AR) on chronic liver injury induced by carbon tetrachloride ( CCl4) in rats. CCl4(20%, 0.5 ml/rat) was given twice a week for 8 weeks, and animals received AR throughout the entire experimental period. AR reduced the elevated levels of serum glutamate-oxalate-transaminase (sGOT) and glutamate-pyruvate-transaminase (sGPT) caused by CCl4at weeks 1,3,6, and 8. The biochemical data were consistent with those of the histological observations. The AR extract recovered the CCl4-induced liver injury and showed antioxidant effect in assays of antioxidant enzyme activity, such as SOD, GSH-Px and GSH-Rd. Based on these results, we suggest that the hepatoprotective effect of the AR is related to its antioxidant activity.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0192415X07004643

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