Hepatoprotective and Anti-oxidant Activities ofGlossogyne tenuifoliaAgainst Acetaminophen-Induced Hepatotoxicity in Mice

Author:

Tien Yu-Hsiu1,Chen Bing-Huei2,Wang Hsu Guoo-Shyng1,Lin Wan-Teng3,Huang Jui-Hua1,Lu Yi-Fa1

Affiliation:

1. Department of Nutritional Science, Fu-Jen Catholic University, New Taipei City 242, Taiwan

2. Department of Food Science, Fu-Jen Catholic University, New Taipei City 242, Taiwan

3. Department of Hospitality Management, Tunghai University, Taichung 407, Taiwan

Abstract

The present study investigated the anti-oxidative and hepatoprotective effects of Glossogyne tenuifolia (GT) Cassini, against acetaminophen-induced acute liver injury in BALB/c mice. The extracts of GT by various solvents (hot water, 50% ethanol and 95% ethanol) were compared for their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, reducing power, total phenolic content, and total anti-oxidant capacity. The results showed that hot water (HW) extracts of GT contained high levels of phenolics and exerted an excellent anti-oxidative capacity; thus, these were used in the animal experiment. The male BALB/c mice were randomly divided into control group, acetaminophen (APAP) group, positive control group and two GT groups at low (GT-L) and high (GT-H) dosages. The results showed that mice treated with GT had significantly decreased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). GT-H increased glutathione levels and the ratios of reduced glutathione and oxidized glutathione (GSH/GSSG) in the liver, and inhibited serum and lipid peroxidation. This experiment was the first to determine phenolic compounds, chlorogenic acid and luteolin-7-glucoside in HW extract of GT. In conclusion, HW extract of GT may have potential anti-oxidant capacity and show hepatoprotective capacities in APAP-induced liver damaged mice.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

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