Anti-Inflammatory Function of Nodosin via Inhibition of IL-2-Reference-Cited by-同舟云学术

Anti-Inflammatory Function of Nodosin via Inhibition of IL-2

Published:2010-01 Issue:01 Volume:38 Page:127-142
ISSN:0192-415X
Container-title:The American Journal of Chinese Medicine
language:en
Short-container-title:Am. J. Chin. Med.

Author:

Li Jiyu¹,Du Junming¹,Sun Lijuan²,Liu Jianwen²,Quan Zhiwei¹

Affiliation:

1. Institute of Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, China

2. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, China

Abstract

In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin. In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum. Finally, Nodosin possessed significant anti-inflammatory effects and is a potential candidate for further clinical trial.

Publisher

World Scientific Pub Co Pte Lt

Subject

Complementary and alternative medicine,General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0192415X10007713

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