Astragalus membranaceus as a Drug Candidate for Inflammatory Bowel Disease: The Preclinical Evidence

Author:

Hou Min1,Leng Yufang12,Shi Yajing1,Tan Zhiguo1,Min Xiangzhen2

Affiliation:

1. The First Clinical Medical College, Lanzhou University, Lanzhou 730000, P. R. China

2. Department of Anesthesiology, The First Hospital of Lanzhou University, Lanzhou 730000, P. R. China

Abstract

Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that include Crohn’s disease (CD) and ulcerative colitis (UC). Today, IBD has no successful treatment. As a result, it is of paramount importance to develop novel therapeutic agents for IBD prevention and treatment. Astragalus membranaceus (AMS) is a traditional Chinese medicine found in the AMS root. Modern pharmacological studies indicate that AMS and its constituents exhibit multiple bioactivities, such as anti-inflammatory, anti-oxidant, immune regulatory, anticancer, hypolipidemic, hypoglycemic, hepatoprotective, expectorant, and diuretic effects. AMS and its active constituents, which have been reported to be effective in IBD treatment, are believed to be viable candidate drugs for IBD treatment. These underlying mechanisms are associated with anti-inflammation, anti-oxidation, immunomodulation, intestinal epithelial repair, gut microbiota homeostasis, and improved energy metabolism. In this review, we summarize the efficacy and underlying mechanisms involved in IBD treatment with AMS and its active constituents in preclinical studies.

Funder

Natural Science Foundation in China

Medical Innovation and Development Project of Lanzhou University

Publisher

World Scientific Pub Co Pte Ltd

Subject

Complementary and alternative medicine,General Medicine

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