Image-based modeling: A novel tool for realistic simulations of artificial bone cultures

Author:

Alam Taseen A.1,Pham Quang L.1,Sikavitsas Vassilios I.2,Papavassiliou Dimitrios V.3,Shambaugh Robert L.3,Voronov Roman S.1ORCID

Affiliation:

1. Otto H. York Department of Chemical, Biological, and Pharmaceutical Engineering, New Jersey Institute of Technology, University Heights, Newark, New Jersey 07102, USA

2. Stephenson School of Biomedical Engineering, The University of Oklahoma, 202 W. Boyd Carson Engineering Center, Room 107, Norman, OK 73019, USA

3. School of Chemical, Biological and Materials Engineering, The University of Oklahoma, 100 East Boyd, SEC T-335, Norman, OK 73019, USA

Abstract

Computational modeling has been promulgated as a means of optimizing artificial bone tissue culturing ex vivo. In the present report, we show, as a proof-of-concept, that it is possible to model the exact microenvironment within the scaffolds while accounting for their architectural complexities and the presence of cells/tissues in their pores. Our results clearly indicate that image-based modeling has the potential to be a powerful tool for computer-assisted tissue engineering.

Funder

Division of Chemical, Bioengineering, Environmental, and Transport Systems

Publisher

World Scientific Pub Co Pte Lt

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