SATURATION EFFECTS FOR CTL MEDIATED CONTROL OF HIV-1 INFECTION: A MATHEMATICAL STUDY

Abstract

The relations between the Human Immunodeficiency Virus-1 (HIV-1) and the human immune system are astonishingly multifaceted, where the critical role for cytotoxic T lymphocytes (CTLs) in the suppression of viral replication in HIV-1 infected individuals cannot be ignored. In this research paper, we have proposed a mathematical model incorporating half saturation constant through the CTL mediated killing process and also in that sense, it has been infiltrated in the generation process of CTL through infected cells. To make the model more realistic, a time lag is introduced in the generation term of CTL population. Also an optimal control theory paradigm is used in our mathematical model to suppress the viral production. From our entire analysis, we have found threshold condition of half saturation constant and treatment schedule so that we can handle the situation of Acquired Immunodeficiency Syndrome (AIDS) patients in a better way. Our analysis reveals that, if the half saturation constant is around 47 mm-3in the saturation process and the drug therapy is to be used around 76 days, then we can get adequate results for better treatment of a HIV-1 patient. Based on numerical results, we observed that in a highly unstable situation, administration of chemotherapy at a high dose can stabilize the system.