Population-based incremental learning for the prediction of Homo sapiens’ protein secondary structure

Abstract

Protein structure prediction is the prediction of the 3D structure of a protein based on its amino acid sequence. It is a key component in disciplines such as medicine, biology, and biochemistry. The prediction of the protein secondary structure of Homo sapiens is one of the more important domains. Many methods have been used to feed forward neural networks or SVMs combined with a sliding window. This method’s mechanisms are too complex to be able to extract clear and straightforward physical meanings from it. This paper explores population-based incremental learning (PBIL), which is a method that combines the mechanisms of a generational genetic algorithm with simple competitive learning. The result shows that its accuracies are particularly associated with the Homo species. This new perspective reveals a number of different possibilities for the purposes of performance improvements.