A Comparative Investigation on the Performance of Different Micro Mixers: Toward Cerebral Microvascular Analysis

Abstract

In this study, a novel fluidic concept was presented to resemble the cerebral microvascular in four types to assess its complexity by using centrifugal platform. The setup consisted of a microstructured disk with a round mixing chamber rotating on a macroscopic drive unit. The left and right internal carotid arteries (L.ICA and R.ICA) and basilar artery (BA) are two isolated vascular system supplying circle of Willis (CoW). The left and right middle cerebral arteries (L.MCA and R.MCA), left and right anterior cerebral arteries (L.ACA and R.ACA), and finally left and right posterior cerebral arteries (L.PCA and R.PCA) constitute efferent arteries of CoW. In this study, cerebral microvascular was investigated by microfluidics approach. The results revealed that a more complex mixing chamber provides normal pixel percentage distribution with respect to the other ones. The outcomes of this study may have implications not only for perception of the intracranial vascular hemodynamic in healthy circumstance, but also for diagnosing the diseases in the blood circulatory system of the human body.