BIOKINETIC MODEL OF Tc-99m MIBI FOR EIGHT PATIENTS UNDERGONE MYOCARDIAL PERFUSION EXAMINATION via GAMMA CAMERA AND MATLAB PROGRAM: AN IN-VIVO STUDY

Author:

YEN YU-CHEN12,TIEN HUI-YUN12,GUO ZHENG-HONG1,WANG TZU-HWEI34,TSAI SHIH-CHUAN2,PAN LUNG-FA15,PAN LUNG-KWANG1

Affiliation:

1. Graduate Institute of Radiological Science, Central Taiwan University of Science and Technology, Takun, Taichung 406, Taiwan, ROC

2. Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan, ROC

3. Department of Radiation Oncology, Yee Zen Hospital, Taoyuan 326, Taiwan, ROC

4. Department of Radiation Oncology, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan, ROC

5. Department of Cardiology, Taichung Armed Forces General Hospital, Taichung 411, Taiwan, ROC

Abstract

Biokinetic model of Tc-99m MIBI for eight patients undergone myocardial perfusion examination was studied using gamma camera and MATLAB program. A six-compartment model was adopted to interpret the metabolic mechanism of each patient. Within the model framework, the respective set of simultaneous differential equations was solved by a self-developed program run in MATLAB. The experimental results exhibited a good fit with the theoretical predictions via the model. The average biological half-lives of body fluid, heart, thyroid, liver, GI Tract and remainder were assessed as [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text][Formula: see text]h, respectively. A dimensionless AT index of disagreement between the experimental data and MATLAB optimal solution was proposed of validating the applied acquisition system and analytical method feasibility. An AT of zero implies a perfect agreement between the theoretical and empirical results, while averages of the derived AT were fluctuated from 3 [Formula: see text] 2 to [Formula: see text] for five compartments. The proposed refined equation estimated the internal dose from gamma-ray as [Formula: see text][Formula: see text]mSv for eight patients according to a fast screening method, which defined human body as a spherical ball to simplify the calculation in reality. The proposed MATLAB-based fitting of in-vivo data with the theoretical results was instrumental for assessing the radiation dose received by the Tc-99m MIBI scan participants.

Funder

Central Taiwan University of Science and Technology

Publisher

World Scientific Pub Co Pte Lt

Subject

Biomedical Engineering

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