HEMODYNAMIC STUDY OF CORONARY ARTERY ANEURYSMS

Abstract

Background: When the coronary artery expands more than two times its diameter, it will form a coronary artery aneurysm (CAA). CAA can lead to myocardial ischemia. In this paper, the mechanism of myocardial ischemia induced by CAA was studied by geometric multiscale method. Methods: Four kinds of three-dimensional models of CAA with different dilation diameters were established on the basis of normal three-dimensional models. The dilation diameters were 2, 3, 5 and 7 times, capacitance was added after the CAA to simulate the elasticity of the vascular wall. Results:A large number of eddies exist in CAA. 2–7 times model: 1.1–14.4% reduction of blood flow downstream of CAA and 5, 7 times model showed upstream diastolic backward flow, the backward flow rate was 1.1% and 5.6%, respectively. The aveWSS at the CAA was 1.76–0.35[Formula: see text]Pa; the relative retention time was 1.1–14.6[Formula: see text]Pa[Formula: see text]; the average vorticity was 0.0085–231.7[Formula: see text]s[Formula: see text]. Conclusion:CAA can store blood, and the elasticity of the wall of CAA results in the flow of blood upstream. These two reasons make the downstream flow of CAA decrease and easily form intratumoral thrombosis, which may lead to myocardial ischemia.