PROTECTIVE MECHANISM OF ALLEVIATING LUNG INJURY BY INHIBITING NF-κB PATHWAY

Abstract

This review is to summarize the reports published in the past 10 years on the protective mechanism of 74 different intervention methods on lung injury through restraining nuclear factor kappa-B (NF-[Formula: see text]B) signaling pathway. We summarized the experimental studies on animal lung injury models of NF-[Formula: see text]B, MAPK/NF-[Formula: see text]B, PI3K/Akt/NF-[Formula: see text]B, TLR4/NF-[Formula: see text]B, NF-[Formula: see text]B/NALP3, NF-[Formula: see text]B/NLRP3 and other NF-[Formula: see text]B-related signal pathways. Lung injury leads to high mortality worldwide. Many potential mechanisms for the treatment and prevention of lung injury are still unclear. In addition to the use of lung protection strategies, currently, there are no effective drugs for lung injury treatment. Preemptive NF-[Formula: see text]B inhibition protects cells from damage, but inhibition at the decomposition stage delays tissue repair. Therefore, we think there is a need to conduct further studies that can provide more insights for future treatment and prevention of lung injury.