EVALUATING THE THEORY OF BONE MECHANOREGULATION IN THE PHYSIOLOGICAL LOADING SCENARIO

Abstract

In this paper, the theory of bone mechanoregulation under physiological loading was evaluated. The entire right tibiae of wild type (WT, [Formula: see text]) and parathyroid hormone (PTH, [Formula: see text]) treated C57BL/6J female mice were scanned using an in vivo [Formula: see text]CT imaging system at 14, 16, 17, 18, 19, 20, 21, and 22 weeks. The PTH intervention started from week 18 until week 22. Subject-specific finite element (FE) models were created from the [Formula: see text]CT images and physiological loading condition was defined in the FE models. The rates of changes in bone mineral content (BMC), bone mineral density (BMD), and bone tissue density (TMD) were quantified over 40 anatomical compartments across the entire mouse tibia. The resulting values were then correlated to the average 1st principal tensile strain ([Formula: see text]) and the strain energy density (SED) for every compartment at weeks 18, 20, and 22. It was found that: in both groups, [Formula: see text] had a minimal effect on the variability of [Formula: see text]BMC ([Formula: see text]); SED had a significant effect on the variability of [Formula: see text]BMC only in the WT group ([Formula: see text]); [Formula: see text] had a significant effect on the variability of [Formula: see text]BMD only in the PTH group ([Formula: see text]); SED had a significant effect on the variability of [Formula: see text]BMD in both groups ([Formula: see text]); neither SED nor [Formula: see text] had a significant effect on the variability of [Formula: see text]TMD ([Formula: see text]). These results are the first to reveal the mechanism of bone mechanoregulation in the physiological loading scenario.