COMPARISON OF THEORIES OF REST TREMOR MECHANISM IN PARKINSON’S DISEASE: CENTRAL OSCILLATOR (SOURCE-TRIGGERED OSCILLATIONS) AND FEEDBACK-INDUCED INSTABILITY IN THE SENSORIMOTOR LOOP (SELF-SUSTAINED OSCILLATIONS)

Author:

SHAH VRUTANGKUMAR V.12,GOYAL SACHIN3,PALANTHANDALAM-MADAPUSI HARISH J.4

Affiliation:

1. Balance Disorder Lab, Department of Neurology, Oregon Health and Science University, OR 97239, USA

2. SysIDEA Lab, Mechanical Engineering, Indian Institute of Technology Gandhinagar, Gandhinagar, GJ-382355, India

3. Department of Mechanical Engineering, Health Science Research Institute, University of California, Merced, CA-95343, USA

4. SysIDEA Lab, Mechanical Engineering, Indian Institute of Technology (IIT), Gandhinagar, GJ-382355, India

Abstract

Rest tremor is one of the most common and disabling symptoms of Parkinson’s disease (PD). The exact neural origin of rest tremor is still not clearly understood. Understanding the origin of rest tremor is important as it may aid in optimizing existing treatment strategies such as Deep Brain Stimulation or in developing new treatment strategies for rest tremor reduction. There are broadly two theories that are gaining prominence for rest tremor generation in PD. The first theory is the central oscillator theory that states that the rest tremor is triggered by an oscillatory source in the brain. The second theory is the feedback-induced instability theory that states that the rest tremor arises out of a feedback-induced instability in the sensorimotor loop. This paper analyzes validity of the two theories based on established clinical observations of Parkinsonian rest tremor by using representative simulation examples. Finally, based on our analysis, we propose two test-worthy experiments for further validation.

Publisher

World Scientific Pub Co Pte Lt

Subject

Biomedical Engineering

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