MECHANICAL PROPERTIES OF GREAT ARTERIAL WALL AND CLINICAL IMPLICATION

Author:

PALLOTTI G.1,PETTAZZONI P.1,BIGI A.2,ROVERI N.2

Affiliation:

1. Faculty of Medicine and Surgery, University of Bologna Viale Berti Pichat, 6/2, 40127 Bologna, Italy

2. Chemistry Department, University of Bologna, Italy

Abstract

X-ray diffraction and microscopic analysis investigate the morphological organization of the structural components in the dog carotid wall. Histological analysis confirms an anisotropic morphology of smooth muscle cells and elastic fibers in the tissue. Collagen fibers, as revealed by X-ray diffraction technique, are organized in an isotropic network in the unstretched carotid media. Collagen fibers stretch without a preferential direction of orientation when a carotid segment is deformed in the physiological range under intraluminal pressure. A mathematical model, which takes into account the isotropic distribution of the collagen fibers, is developed. The validity of this model has been tested by computing several mechanical parameters using Anliker's data on the axial and radial oscillation obtained for carotids of living dogs. In spite of the anisotropic morphology of the main constituents of the carotid media layer, from a mechanical point of view the tissue can be considered as an isotropic material for the random distribution of the collagen fibers, which represent the component of higher tensile strength.

Publisher

World Scientific Pub Co Pte Lt

Subject

Biomedical Engineering

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Donor/Recipient Delta Age: A Possible Risk for Arterial Stenosis in Renal Transplantation;Computational and Mathematical Methods in Medicine;2015

2. ARTERIAL WALL MECHANICAL PROPERTIES AND KIDNEY GRAFT ARTERIAL STENOSIS;Journal of Mechanics in Medicine and Biology;2006-06

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