ANALYSES OF BRAIN CORTICAL CHANGES OF ALZHEIMER’S DISEASE

Abstract

Alzheimer’s disease (AD) produces complicated cortical changes in gray matter (GM) of the human brain. However, alterations in the brain cortex have not been clearly addressed. In our study, a cohort of 236 cases MR data enrolled from the ADNI database was categorized into three groups of normal controls (NCs), mild cognitive impairment (MCI) and AD. The GM morphological differences were investigated among the three groups using the magnetic resonance (MR) GM characteristics of gray matter volume (GMV), cortical thickness (CT), cortical surface area (CSA) and local gyrification index (LGI) at the three levels of whole brain, bilateral hemispheres and critical brain regions. Totally, there were six critical brain regions for GMV, 11 for CT, 2 for CSA and 59 for LGI among the three groups for the no-division groups. Also, there were 11 critical brain regions for GMV, 15 for CT, 8 for CSA, 3 for LGI for female sub-groups and 4 critical brain regions for GMV, 11 for CT, 1 for CSA, 3 for LGI for male sub-groups. The four measured cortical characteristics showed reliable capability in the morphological description of GM changes of AD. In conclusion, the cortical characteristics of GMV, CT, CSA and LGI of critical brain regions showed valuable indications for GM changes of AD, and those characteristics could be used as imaging markers for AD prediction.