PHYSIOLOGICAL PARAMETERS AND SEVERITY OF CORONAVIRUS INFECTION: CASE STUDY

Abstract

Preface: Coronavirus has several mechanisms that facilitate its entry into the target cell such as cholesterol by acting concurrently with angiotensin-converting enzyme (ACE2) at entry site, where the virus uses it to increase its entry and spread. We conducted a practical research for measuring Cholesterol, Triglyceride (TG) and Lactate dehydrogenase concentrations in COVID-19 patients. Objectives: The aim of this research is to see the correlation between Cholesterol, TG and Lactate dehydrogenase and the severity of coronavirus infection. Methods: This study is made at Al-Zahra Teaching Hospital during the period from March 2021 to July 2021 and it was performed on two groups: patients group that involved 30 samples (15 male and 15 female), age ranging from 18 to 84 years old and another group consisting of 30 individuals who were not infected with SARS-CoV-2. Results: Our findings show that the high value for markers under this study associated with coronavirus was detected in lactate dehydrogenase ([Formula: see text] IU/l), ([Formula: see text] Mg/dl) for TG and ([Formula: see text] Mg/dl) for cholesterol. High concentration of cholesterol is shown in the age category between 54 and 64 years is represented as (487 Mg/dl and 502 Mg/dl), TG at ages 42, 54 and 64 years is represented as 497, 509 and 521 Mg/dl, Lactate dehydrogenase at ages 80–84 years that represented is as 739, 809 and 812 IU/l. According to physiological parameters which were elevated, a high concentration was observed in almost both sexes, as males were more affected than females when determining cholesterol at (500 Mg/dl), while females had more than males with respect to lactate dehydrogenase and TGs at (520 Mg/dl and 800 IU/l), respectively. In the correlation test, we found the highest significant differences, according to the correlation test, between cholesterol and lactate dehydrogenase at (1) cholesterol and TG at (0.000), TG and lactate dehydrogenase at (0.739). Conclusions: We conclude that COVID-19 patients suffer from increased markers under the studies on cholesterol, TG and lactate dehydrogenase.