FUZZY-BASED ANALYSIS OF MICROSCOPIC COLOR CERVICAL PAP SMEAR IMAGES: NUCLEI DETECTION

Abstract

The Pap Smear test, or cervico-vaginal cytology, is globally the most used and suitable method for screening cervical cancer precursor lesions, with a significant impact in reducing the incidence and mortality rates. However, Pap test suffers from subjective variability and no specificity, being the most controversial point the persistence of false negatives; i.e., normal cytological report for a woman with existing dysplasia, pre-malignant, or malignant lesions of the cervix. This is due in large part to the vast number of cells that must be reviewed by a technician for determining the possible existence of a small number of malignant or pre-malignant cells. Automated systems that include technician knowledge and interpretation could not only reduce sample examination time but also avoid misclassification of samples because of human errors. Here we present part of our ongoing work toward automation of cervical screening process. Specifically, since in cytological studies nuclei are considered the most informative regions, and an accurate segmentation is needed for extracting meaningful cell features, we propose an automated nuclei detection algorithm that integrates color information, cytopathologists knowledge, and fuzzy systems. Results have shown that besides a high performance and efficiency, the speed of the algorithm is very high.