Feature Selection in GPCR Classification Using BAT Algorithm

Abstract

G-Protein-Coupled Receptors (GPCR) are the large family of protein membrane; and until now some of them still remain orphans. Predicting GPCR functions is a challenging task, it depends closely to their classification, which requires a digital representation of each protein chain as an attribute vector. A major problem of GPCR databases is their great number of features which can produce combinatorial explosion and increase the complexity of classification algorithms. Feature selection techniques are used to deal with this problem by minimizing features space dimension, and keeping the most relevant ones. In this paper, we propose to use the BAT algorithm for extracting the pertinent features and to improve the classification results. We compared the results obtained by our system with two other bio-inspired algorithms, Evolutionary Algorithm and PSO search. Metrics quality measures used for comparison are Error Rate, Accuracy, MCC and [Formula: see text]-measure. Experimental results indicate that our system is more efficient.