Affiliation:
1. Department of Dynamics and Control, Beihang University, Beijing 100191, P. R. China
2. School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, P. R. China
Abstract
The transiting mechanism of abnormal brain functional activities, such as the epileptic seizures, has not been fully elucidated. In this study, we employ a probabilistic neural network model to investigate the impact of negative regulation, including negative connections and negative inputs, on the dynamical transition behavior of network dynamics. It is observed that negative connections significantly influence the transition behavior of the network, intensifying the oscillation of discharge probability, corresponding to uneven discharge and epileptic states. Negative inputs, within a certain range, exhibited a similar impact on the dynamic state of the network as negative connections, enhancing network oscillations and resulting in higher fragility. However, larger negative inputs can led to the disappearance of oscillations in the discharge probability, indicating a maintenance of lower fragility. We speculate that negative regulation may be an indispensable factor in the occurrence of epileptic seizures, and future research should give it due consideration.
Funder
National Natural Science Foundation of China
Publisher
World Scientific Pub Co Pte Ltd