BLOCK ENTROPY ANALYSIS OF HEART RATE VARIABILITY SIGNALS

Author:

KARAMANOS K.1,NIKOLOPOULOS S.2,HIZANIDIS K.2,MANIS G.3,ALEXANDRIDI A.4,NIKOLAKEAS S.5

Affiliation:

1. Centre for Nonlinear Phenomena and Complex Systems, Universite Libre de Bruxelles, CP 213, Campus Plaine, B-1050 Brussels, Belgium

2. National Technical University of Athens, Department of Electrical and Computer Engineering, Iroon Polytechniou 9, GR-15773, Zografou Campus, Greece

3. University of Ioannina, Department of Computer Science, P.O. Box. 1186, GR-45110, Ioannina, Greece

4. Foundation of Biomedical Research of the Academy of Athens, 4 Soronou Efesiou Str 11527 Athens, Greece

5. Athens Air Force and Veterans Hospital, Department of Cardiology, P. Kanellopoulos St, Athens, Greece

Abstract

In this paper we present a novel approach to the analysis of Heat Rate Variability (HRV) data, by coarse-graining analysis using the estimation of Block Entropies with the technique of lumping. HRV time series are generated from long recordings of Electrocardiograms (ECGs) and are then filtered in order to produce a coarse-grained symbolic dynamics. Block Entropy analysis is applied to these dynamics in order to examine its coarse-grained statistics. Our data set is comprised of two subsets, one of healthy subjects and another of Coronary Artery Disease (CAD) patients. It is found that Entropy analysis provides a quick and efficient tool for the differentiation of these series according to subject category. Healthy subjects provided more complex statistics compared to patients; specifically, the healthy data files provided higher values of block Entropies compared to patient ones. We also compare these results with the Correlation Dimension Estimation in order to establish coherency. We believe that this analysis may provide a useful statistical method towards the better understanding of the human cardiac system.

Publisher

World Scientific Pub Co Pte Lt

Subject

Applied Mathematics,Modelling and Simulation,Engineering (miscellaneous)

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