IN-SILICO MODELING OF LEFT VENTRICLE TO SIMULATE DILATED CARDIOMYOPATHY AND CF-LVAD SUPPORT

Abstract

Numerical modeling of the left ventricle dynamics plays an important role in testing different physiological scenarios and treatment techniques before the in vitro and in vivo assessments. However, utilized left ventricle model becomes vital in the simulations because validity of the results depends on the response of the numerical model to the parameter changes and additional sub-models for the applied treatment techniques. In this study, it is aimed to evaluate different numerical left ventricle models describing healthy and failing ventricle dynamics as well as the response of these models under continuous flow left ventricular assist device support. Six different numerical left ventricle models which include time varying elastance and single fiber contraction approaches are selected and applied in combination with a closed loop electric analogue of the circulation to achieve this purpose. The time varying elastace models relate ventricular pressure and volume changes in a simplistic way while the single fiber contraction models combine different scales ranging from protein to organ level. Change of the hemodynamic signals at the organ level for healthy, failing and CF-LVAD supported left ventricle models shows functionality of these models and helps to understand usability of them for different purposes.