ANALYSIS OF AN AGE-STRUCTURED HIV-1 INFECTION MODEL WITH LOGISTIC TARGET CELL GROWTH

Author:

LIU HUIJUAN1,XU FEI2,ZHANG JIA-FANG1

Affiliation:

1. School of Mathematics and Statistics, Henan University, Kaifeng, Henan 475001, P. R. China

2. Department of Mathematics, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5, Canada

Abstract

In this work, we construct an age-structured HIV-1 infection model to investigate the interplay between [Formula: see text] cells and viruses. In our model, we assume that the variations in the death rate of productively infected [Formula: see text] cells and the production rate of virus in infected cells are all age-dependent, and the target cells follow logistic growth. We perform mathematical analysis and prove the persistence of the semi-flow of the system. We calculate the basic reproduction number and prove the local and global stability of the steady states. We show that if the basic reproduction number is less than one, the disease-free equilibrium is globally asymptotically stable, and if the basic reproduction number is greater than one, the infected steady state is locally asymptotically stable.

Publisher

World Scientific Pub Co Pte Lt

Subject

Applied Mathematics,Agricultural and Biological Sciences (miscellaneous),Ecology,Applied Mathematics,Agricultural and Biological Sciences (miscellaneous),Ecology

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