DYNAMICAL ANALYSIS OF TB MODEL WITH NONLINEAR INCIDENCE RATE AND OPTIMAL CONTROL

Abstract

We propose and analyze a TB transmission model with nonlinear incidence rate, immunization and medical treatment. First, the existences and stabilities of the equilibrium are studied. The results indicate the basic reproduction number [Formula: see text] is the threshold of disease extinction and persistence. The disease-free equilibrium is globally asymptotically stable when [Formula: see text], and the disease will gradually disappear. The unique positive equilibrium is local stability and the disease is uniformly persistent when [Formula: see text]. Second, optimal control is added to the original model because of limited resources. Finally, the stability of the equilibrium and the theoretical results of optimal control are verified by numerical simulations, and the sensitivity of the parameters is analyzed by the PRCC method.