THE DYNAMICS OF HIV MODELS WITH SWITCHING PARAMETERS AND PULSE CONTROL

Abstract

This paper studies some human immunodeficiency virus (HIV) models with switching parameters and pulse control. The classical virus dynamics model is first modified by incorporating switching parameters which are assumed to be time-varying. Some threshold conditions are derived to guarantee the virus elimination by utilizing a Razumikhin-type approach. The results show that the proper switching conditions chosen can increase the counts of CD4+T-cells while reducing viral load. Pulse control strategies are then applied to the above model. More precisely, the treatment strategy and the vaccination strategy are applied to infected cells and uninfected cells, respectively. Each control strategy is analyzed to gauge its success in achieving viral suppression. Numerical simulations are performed to complement the analytical results and motivate future directions.