NOT THAT RIGID MIDGETS AND NOT SO FLEXIBLE GIANTS: ON THE ABUNDANCE AND ROLES OF INTRINSIC DISORDER IN SHORT AND LONG PROTEINS-Reference-Cited by-同舟云学术

NOT THAT RIGID MIDGETS AND NOT SO FLEXIBLE GIANTS: ON THE ABUNDANCE AND ROLES OF INTRINSIC DISORDER IN SHORT AND LONG PROTEINS

Published:2012-12 Issue:04 Volume:20 Page:471-511
ISSN:0218-3390
Container-title:Journal of Biological Systems
language:en
Short-container-title:J. Biol. Syst.

Author:

HOWELL MARK¹,GREEN RYAN¹,KILLEEN ALEXIS¹,WEDDERBURN LAMAR¹,PICASCIO VINCENT¹,RABIONET ALEJANDRO¹,PENG ZHENLING²,LARINA MAYA³,XUE BIN¹,KURGAN LUKASZ²,UVERSKY VLADIMIR N.⁴⁵

Affiliation:

1. Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, USA

2. Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada

3. Department of Mathematics and Informatics, College of Medical Biochemistry, Volgograd State Medical University, 400131 Volgograd, Russia

4. Department of Molecular Medicine, USF Health Byrd Alzheimer's Research Institute, College of Medicine, University of South Florida, Tampa, FL 33612, USA

5. Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia

Abstract

Intrinsically disordered proteins or proteins with disordered regions are very common in nature. These proteins have numerous biological functions which are complementary to the biological activities of traditional ordered proteins. A noticeable difference in the amino acid sequences encoding long and short disordered regions was found and this difference was used in the development of length-dependent predictors of intrinsic disorder. In this study, we analyze the scaling of intrinsic disorder in eukaryotic proteins and investigate the presence of length-dependent functions attributed to proteins containing long disordered regions.

Publisher

World Scientific Pub Co Pte Ltd

Subject

Applied Mathematics,Agricultural and Biological Sciences (miscellaneous),Ecology,Applied Mathematics,Agricultural and Biological Sciences (miscellaneous),Ecology

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0218339012400086

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