An Efficient Clicked Degradable Template Model Responsive to Encapsulation and Release of Fluorescent Dye

Abstract

We invoked one-step synthesis for degradable organogel material via metal-free thiol-alkene click chemistry. The thermally clicked hydrothiolation formed ester-based xerogel. The xerogel showed switch in swellability with switch of solvent polarity. Though the material showed no response in swellability to solvents of low-polarity index but swelled in organic polar and chlorinated solvents. Encapsulation and release of 8-hydroxyquinoline were studied. The analyzed xerogel showed thermal stability analyzed using thermogravimetric analysis. The degradability at 6N HCl is unique, which was well monitored via time-dependent release of encapsulated 8-hydroxyquinoline. Cryo TEM analysis revealed such nanogel can prove to be a vital model to carry encapsulated low molecular weight (LMW) drug and efficient release at [Formula: see text] via self-degradation.