COLLECTIVE BEHAVIORS OF SPIRAL WAVES IN THE NETWORKS OF HODGKIN-HUXLEY NEURONS IN PRESENCE OF CHANNEL NOISE

Abstract

Collective behaviors of spiral waves in the networks of Hodgkin-Huxley neuron are investigated. A stable rotating spiral wave can be developed to occupy the quiescent areas in networks of neurons by selecting appropriate initial values for the variables in the networks of neurons. In our numerical studies, most neurons are quiescent and finite (few) numbers of neurons are selected with different values to form a spiral seed. In this way, neurons communicating are carried by propagating spiral wave to break through the quiescent domains (areas) in networks of neurons. The effect of membrane temperature on the formation of spiral wave is investigated by selecting different fixed membrane temperatures in the networks, and it is found that a spiral wave cannot be developed if the membrane temperature is close to a certain threshold. A quantitative factor of synchronization is defined to measure the statistical properties and collective behaviors of the spiral wave. And a distinct phase transition, which indicates the critical condition for spiral survival, is observed in the sudden changing point of the factors of synchronization curve vs. certain bifurcation parameter. Internal noise is introduced into ion channels (channel noise) with the Langevin method. It is found that a stable rotating spiral wave is developed and the spiral wave is robust to weak channel noise (the membrane patch is not small). The spiral wave can not grow up and the stable rotating spiral wave encounters instability in presence of strong channel noise. Coherence resonance-like behavior is observed in calculating the factors of synchronization in presence of channel noise.