LOCOMOTION OF A TWO DIMENSIONAL KERATOCYTE MODEL

Abstract

The polymerization-induced propulsion of a model cell consisting of a cell membrane enclosing mobile actin molecules and polymerizing actin filaments is studied using Monte Carlo methods. It is shown that asymmetric polymerization alone induces a rectified motion of the cell. The structural organization of the locomoting cell exhibits an anisotropic shape induced by the anisotropic distribution of actin within the cell. This nonequilibrium distribution is maintained by a constant flow of actin molecules from the rear to the front of the cell. The efficiency of the rectification process, and hence the cell velocity, depends cooperatively on the density of actin molecules. The maximum of the cell velocity is determined by the optimal interplay between the number of filaments and the fluctuation of the cell membrane.