CONTROL STRATEGIES of HEPATITIS B WITH THREE CONTROL VARIABLES

Abstract

In this paper, we present a compartmental mathematical model of hepatitis B virus with optimal control strategies. First, we formulate the model applying the optimal control techniques which use control variables in the form of isolation, educational campaign and vaccination. We derive the conditions under which it is optimal to eradicate the disease and examine the impact of possible vaccination treatment strategies on disease transmission. When such an elimination is impossible, we use the techniques of Pontryagin’s Maximum Principle to derive the necessary conditions for the optimal control problem. The numerical results show that some effective vaccination and control can reduce the disease spread in the community.