EFFECTS OF WHOLE-BODY VIBRATION ON MUSCLE STRENGTH, BALANCE AND FUNCTIONAL MOBILITY IN PATIENTS WITH MULTIPLE SCLEROSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract

Multiple sclerosis (MS) is a type of degenerative syndrome that causes impaired physical function, decreased walking, imbalance, spasticity, sensory impairment, muscle weakness, fatigue, and demyelination of the central nervous system. The purpose of this review was to critically examine available studies on the efficacy of whole-body vibration (WBV) in patients with MS during rehabilitation training to increase strength, balance, and functional mobility. An organized literature search was performed on databases from various sources, including PubMed, MEDLINE, CINAHL, and EMBASE, to identify relevant randomized clinical trials (RCTs). Eight studies were finally selected based on exclusion and inclusion criteria. Attempts were made to identify factors affecting the improvement in muscle strength, balance, and functional mobility in MS patients as a result of WBV. A meta-analysis was performed if two or more studies measured the same outcome of interest. The meta-analysis found that the WBV intervention showed significant improvement over control groups in Body Balance Score (BBS) (MD = [Formula: see text]2.86, 95%CI = [Formula: see text]5.29 [Formula: see text] 0.43; [Formula: see text], [Formula: see text], heterogeneity ([Formula: see text]%). In addition, walking endurance (6MWT) favored control groups over WBV intervention (MD [Formula: see text], 95%CI [Formula: see text][Formula: see text] 99.41; [Formula: see text] = 2.97, [Formula: see text]). Timed-Up-and-Go Test (TUG) and Expanded Disability Status Scale (EDSS) ([Formula: see text]) had no significant effect on WBV. Restoration of balance and functional mobility appeared to respond better to WBV with additional exercise protocols compared to WBV alone. Although there is evidence of an overall effect of WBV on strength and some measures of balance and mobility, its impact remains inconclusive. Therefore, more robust RCTs examining exposure to WBV on balance and functional mobility in patients with MS are warranted.