3D IMAGING OF HUMAN CELLS BY USING PIXE-µ-CT-Reference-Cited by-同舟云学术

3D IMAGING OF HUMAN CELLS BY USING PIXE-µ-CT

Published:2009-01 Issue:01n02 Volume:19 Page:29-37
ISSN:0129-0835
Container-title:International Journal of PIXE
language:en
Short-container-title:Int. J. PIXE

Author:

KAWAMURA Y.¹,ISHII K.¹,MATSUYAMA S.¹,NAKHOSTIN M.¹,FUJIWARA M.¹,WATANABE M.¹,OKURA S.¹,HAMADA N.¹,TSUBOI S.¹,YAMANAKA K.¹,HASHIMOTO Y.¹,FUJIKAWA M.¹,CATELLA G.¹,HATORI Y.¹,FUJIKI K.¹,YAMAZAKI H.²,ORTEGA R.³,DEVES G.³,CARMONA A.³

Affiliation:

1. Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

2. Cyclotron Radioisotope Center, Tohoku University, Sendai 980-8578, Japan

3. CNAB, CNRS Universite Bordeaux 1, BP120 Le Haut Vigneau, 33175 Gradignan, France

Abstract

Particulate matter (PM) such as chromium compound ( PbCrO 4) is highly cytotoxic and carcinogenic. Several hexavalent chromium, compounds, Cr ( VI ), compounds are known to generate hydroxyl radical with in the cell and contribute to tissue damage. The way that theses compounds interact with human bodies at a cellular level is still unknown. To investigate the intracellular mechanism of chromium compounds, the 3D imaging techniques at the micro level are needed. In this paper, we report on the improvement of the PIXE-µ-CT system which was developed at Tohoku University and measured intracellular distribution images of PbCrO 4.particles on human lung cell.

Publisher

World Scientific Pub Co Pte Lt

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0129083509001710

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