GENE THERAPY FOR RHEUMATOID ARTHRITIS-Reference-Cited by-同舟云学术

GENE THERAPY FOR RHEUMATOID ARTHRITIS

Published:2001-12 Issue:02 Volume:06 Page:211-219
ISSN:0218-8104
Container-title:Hand Surgery
language:en
Short-container-title:Hand Surg.

Author:

Gouze Jean-Noel¹²,Ghivizzani Steven C.¹,Gouze Elvire¹,Palmer Glyn. D.¹,Betz Oliver B.¹,Robbins Paul D.³,Evans Christopher H.¹,Herndon James H.⁴

Affiliation:

1. Department of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA

2. EECS, Massachusetts Institute of Technology, Cambridge, MA, USA

3. Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

4. Department of Orthopedic Surgery, Massachusetts General Hospital, Cambridge, MA, USA

Abstract

Advances in understanding the biology of rheumatoid arthritis (RA) have opened new therapeutic avenues. One of these, gene therapy, involves the delivery to patients of genes encoding anti-arthritic proteins. This approach has shown efficacy in animal models of RA, and the first human, phase I trial has just been successfully completed. Hand surgery featured prominently in this pioneering study, as a potentially anti-arthritic gene encoding the interleukin-1 receptor antagonist was transferred to the metacarpophalangeal joints of subjects with RA one week before total joint arthroplasty. This study has confirmed that it is possible to transfer genes safely to human joints. It should pave the way for additional application of gene therapy to arthritis and other orthopaedic conditions.

Publisher

World Scientific Pub Co Pte Lt

Subject

General Medicine

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0218810401000709

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