Investigation of a novel triazatetrabenzcorrole photosensitizer

Author:

Song Zhenglin1,Zhang Fushi1,Li Xue1,Chan Shek-Kiu2,Zhao Fuqun1,Tang Yingwu1

Affiliation:

1. Department of Chemistry, Tsinghua University, Beijing 100084, China

2. Faculty of Science & Technology, University of Macau, Macau, China

Abstract

A novel phthalocyanine-like photosensitizer, oxophosphorus(V) tetrasulfotriaza-tetrabenzcorrole ( POTBCS 4), has been synthesized. Its structure and absorption spectrum are unique. POTBCS 4 has an axial P = O group and peripheral sulfo groups. The fluorescence emission spectra, fluorescence quantum yield and quantum yield of singlet oxygen generation have been studied. The uptake and the photodynamic activities against HeLa cells were measured. The results indicated that POTBCS 4 was a potential photosensitizer for photodynamic therapy (PDT).

Publisher

World Scientific Pub Co Pte Lt

Subject

General Chemistry

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